区别如下：
1. 意思不同： "What does he like?" 询问的是对方的兴趣爱好，即他喜欢什么事物。
"What is he like?" 询问的是对方的性格、外貌或行为特征，即他是怎样的人。
2. 用法不同： "What does he like?" 是一个特殊疑问句，用于询问对方的喜好，需要用助动词"does"来构成疑问句。例如：What does he like to do in his free time?
"What is he like?" 是一个普通疑问句，用于询问对方的性格、外貌或行为特征，不需要助动词。例如：What is he like as a boss?
3. 侧重点不同： "What does he like?" 侧重于了解对方的兴趣爱好，帮助了解他的个人爱好和喜好。
"What is he like?" 侧重于了解对方的个性、性格特征和外貌，帮助了解他的人格和行为习惯。
总之，"What does he like?" 询问的是喜好，而"What is he like?" 询问的是对方的性格和外貌特征。
what does he like与what is he like的区别
两句话意思根本不同,
What does he like?
他喜欢什么?
What is he like
他长什么样?